Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1

Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1

<p>Abstract</p> <p>The mechanisms underlying the Hepatitis C virus (HCV) resistance to interferon alpha (IFN-α) are not fully understood. We used IFN-α resistant HCV replicon cell lines and an infectious HCV cell culture system to elucidate the mechanisms of IFN-α resistance in cel...

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Bibliographic Details
Main Authors: Lamaze Christophe, Koster Mario, Hauser Hansjorg, Wimley William C, Gunduz Feyza, Poat Bret, Samara¹ Maria, Chandra Partha K, Hazari Sidhartha, Datta Sibnarayan, Balart Luis A, Garry Robert F, Dash Srikanta
Format: Article
Language:English
Published: BMC 2011-07-01
Series:Virology Journal
Subjects:
Hepatitis C virus (HCV)
Interferon alpha (IFN-α)
Interferon alpha-receptor 1 (IFNAR1)
Jak-Stat signaling
nuclear translocation
reverse transcription polymerase chain reaction (RT-PCR)
HCV infection
ER stress
Online Access:http://www.virologyj.com/content/8/1/351

Internet

http://www.virologyj.com/content/8/1/351

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