Wen-Luo-Tong Decoction Attenuates Paclitaxel-Induced Peripheral Neuropathy by Regulating Linoleic Acid and Glycerophospholipid Metabolism Pathways

Wen-Luo-Tong Decoction Attenuates Paclitaxel-Induced Peripheral Neuropathy by Regulating Linoleic Acid and Glycerophospholipid Metabolism Pathways

Chemotherapy-induced peripheral neuropathy (CIPN) is a serious dose-limiting toxicity of many anti-neoplastic agents, especially paclitaxel, and oxaliplatin. Up to 62% of patients receiving paclitaxel regimens turn out to develop CIPN. Unfortunately, there are so few agents proved effective for prev...

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Bibliographic Details
Main Authors: Fei-ze Wu, Wen-juan Xu, Bo Deng, Si-da Liu, Chao Deng, Meng-yu Wu, Yu Gao, Li-qun Jia
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
paclitaxel
peripheral neuropathy
metabolomics
Wen-Luo-Tong (WLT)
TCM
UHPLC-MS/MS
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00956/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00956/full

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