Cdk1-mediated phosphorylation of human ATF7 at Thr-51 and Thr-53 promotes cell-cycle progression into M phase.

Cdk1-mediated phosphorylation of human ATF7 at Thr-51 and Thr-53 promotes cell-cycle progression into M phase.

Activating transcription factor 2 (ATF2) and its homolog ATF7 are phosphorylated at Thr-69/Thr-71 and at Thr-51/Thr-53, respectively, by stress-activated MAPKs regulating their transcriptional functions in G1 and S phases. However, little is known about the role of ATF2 and ATF7 in G2/M phase. Here,...

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Bibliographic Details
Main Authors: Hitomi Hasegawa, Kenichi Ishibashi, Shoichi Kubota, Chihiro Yamaguchi, Ryuzaburo Yuki, Haruna Nakajo, Richard Eckner, Noritaka Yamaguchi, Kazunari K Yokoyama, Naoto Yamaguchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0116048

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https://doi.org/10.1371/journal.pone.0116048

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