Antibody Afucosylation Augments CD16-Mediated Serial Killing and IFNγ Secretion by Human Natural Killer Cells

Antibody Afucosylation Augments CD16-Mediated Serial Killing and IFNγ Secretion by Human Natural Killer Cells

One mechanism by which monoclonal antibodies (mAb) help treat cancer or autoimmune disease is through triggering antibody-dependent cellular cytotoxicity (ADCC) via CD16 on Natural Killer (NK) cells. Afucosylation is known to increase the affinity of mAbs for CD16 on NK cells and here, we set out to...

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Bibliographic Details
Main Authors: Alexandros Karampatzakis, Petr Brož, Camille Rey, Björn Önfelt, Gabriela Dos Santos Cruz De Matos, Daniel Rycroft, Ashley Ambrose, Daniel M. Davis
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
Natural Killer cells
antibody dependent cellular cytotoxicity
Fc receptors
afucosylation
cellular activation
immune synapse
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.641521/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.641521/full

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