Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro‐Oxindole Dihydroquinazolinones as IRAP Inhibitors

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro‐Oxindole Dihydroquinazolinones as IRAP Inhibitors

Abstract Insulin‐regulated aminopeptidase (IRAP) is a new potential macromolecular target for drugs aimed for treatment of cognitive disorders. Inhibition of IRAP by angiotensin IV (Ang IV) improves the memory and learning in rats. The majority of the known IRAP inhibitors are peptidic in character...

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Bibliographic Details
Main Authors: Karin Engen, Dr. Sudarsana Reddy Vanga, Dr. Thomas Lundbäck, Dr. Faith Agalo, Vivek Konda, Dr. Annika Jenmalm Jensen, Prof. Johan Åqvist, Dr. Hugo Gutiérrez‐de‐Terán, Prof. Dr. Mathias Hallberg, Prof. Dr. Mats Larhed, Dr. Ulrika Rosenström
Format: Article
Language:English
Published: Wiley-VCH 2020-03-01
Series:ChemistryOpen
Subjects:
enzymes
inhibitors
insulin-regulated aminopeptidases
preclinical profiling
spiro compounds
Online Access:https://doi.org/10.1002/open.201900344

Internet

https://doi.org/10.1002/open.201900344

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