A Novel Hybrid CNN-SVR for CRISPR/Cas9 Guide RNA Activity Prediction

A Novel Hybrid CNN-SVR for CRISPR/Cas9 Guide RNA Activity Prediction

Accurate prediction of guide RNA (gRNA) on-target efficacy is critical for effective application of CRISPR/Cas9 system. Although some machine learning-based and convolutional neural network (CNN)-based methods have been proposed, prediction accuracy remains to be improved. Here, firstly we improved...

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Bibliographic Details
Main Authors: Guishan Zhang, Zhiming Dai, Xianhua Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Genetics
Subjects:
CRISPR/Cas9
guide RNA
convolutional neural network
on-target
support vector regression
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01303/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.01303/full

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