A new role for TIMP-1 in modulating neurite outgrowth and morphology of cortical neurons.

BACKGROUND:Tissue inhibitor of metalloproteinases-1 (TIMP-1) displays pleiotropic activities, both dependent and independent of its inhibitory activity on matrix metalloproteinases (MMPs). In the central nervous system (CNS), TIMP-1 is strongly upregulated in reactive astrocytes and cortical neurons...

Full description

Bibliographic Details
Main Authors: Adlane Ould-yahoui, Evelyne Tremblay, Oualid Sbai, Lotfi Ferhat, Anne Bernard, Eliane Charrat, Yatma Gueye, Ngee Han Lim, Keith Brew, Jean-Jacques Risso, Vincent Dive, Michel Khrestchatisky, Santiago Rivera
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2788270?pdf=render