MicroRNA-31 Reduces the Motility of Proinflammatory T Helper 1 Lymphocytes

MicroRNA-31 Reduces the Motility of Proinflammatory T Helper 1 Lymphocytes

Proinflammatory type 1 T helper (Th1) cells are enriched in inflamed tissues and contribute to the maintenance of chronic inflammation in rheumatic diseases. Here we show that the microRNA- (miR-) 31 is upregulated in murine Th1 cells with a history of repeated reactivation and in memory Th cells is...

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Bibliographic Details
Main Authors: Markus Bardua, Claudia Haftmann, Pawel Durek, Kerstin Westendorf, Antje Buttgereit, Cam Loan Tran, Mairi McGrath, Melanie Weber, Katrin Lehmann, Richard Kwasi Addo, Gitta Anne Heinz, Anna-Barbara Stittrich, Patrick Maschmeyer, Helena Radbruch, Michael Lohoff, Hyun-Dong Chang, Andreas Radbruch, Mir-Farzin Mashreghi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
CD4
miR-31
miRNA
target identification
T cell migration
Th1 cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02813/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02813/full

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