Sensitive detection of multiple islet autoantibodies in type 1 diabetes using small sample volumes by agglutination-PCR.

Sensitive detection of multiple islet autoantibodies in type 1 diabetes using small sample volumes by agglutination-PCR.

Islet autoantibodies are predominantly measured by radioassay to facilitate risk assessment and diagnosis of type 1 diabetes. However, the reliance on radioactive components, large sample volumes and limited throughput renders radioassay testing costly and challenging. We developed a multiplex analy...

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Bibliographic Details
Main Authors: Felipe de Jesus Cortez, David Gebhart, Peter V Robinson, David Seftel, Narges Pourmandi, Jordan Owyoung, Carolyn R Bertozzi, Darrell M Wilson, David M Maahs, Bruce A Buckingham, John R Mills, Matthew M Roforth, Sean J Pittock, Andrew McKeon, Kara Page, Wendy A Wolf, Srinath Sanda, Cate Speake, Carla J Greenbaum, Cheng-Ting Tsai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0242049

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https://doi.org/10.1371/journal.pone.0242049

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