In vitro evolution of allergy vaccine candidates, with maintained structure, but reduced B cell and T cell activation capacity.

In vitro evolution of allergy vaccine candidates, with maintained structure, but reduced B cell and T cell activation capacity.

Allergy and asthma to cat (Felis domesticus) affects about 10% of the population in affluent countries. Immediate allergic symptoms are primarily mediated via IgE antibodies binding to B cell epitopes, whereas late phase inflammatory reactions are mediated via activated T cell recognition of allerge...

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Bibliographic Details
Main Authors: Ola B Nilsson, Justus Adedoyin, Claudio Rhyner, Theresa Neimert-Andersson, Jeanette Grundström, Kurt D Berndt, Reto Crameri, Hans Grönlund
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3172221?pdf=render

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http://europepmc.org/articles/PMC3172221?pdf=render

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