Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor

Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor

Abstract The FGFR1 gene encoding fibroblast growth factor receptor 1 has emerged as a frequently altered oncogene in the pathogenesis of multiple low-grade neuroepithelial tumor (LGNET) subtypes including pilocytic astrocytoma, dysembryoplastic neuroepithelial tumor (DNT), rosette-forming glioneuron...

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Bibliographic Details
Main Authors: Calixto-Hope G. Lucas, Rohit Gupta, Pamela Doo, Julieann C. Lee, Cathryn R. Cadwell, Biswarathan Ramani, Jeffrey W. Hofmann, Emily A. Sloan, Bette K. Kleinschmidt-DeMasters, Han S. Lee, Matthew D. Wood, Marjorie Grafe, Donald Born, Hannes Vogel, Shahriar Salamat, Diane Puccetti, David Scharnhorst, David Samuel, Tabitha Cooney, Elaine Cham, Lee-way Jin, Ziad Khatib, Ossama Maher, Gabriel Chamyan, Carole Brathwaite, Serguei Bannykh, Sabine Mueller, Cassie N. Kline, Anu Banerjee, Alyssa Reddy, Jennie W. Taylor, Jennifer L. Clarke, Nancy Ann Oberheim Bush, Nicholas Butowski, Nalin Gupta, Kurtis I. Auguste, Peter P. Sun, Jarod L. Roland, Corey Raffel, Manish K. Aghi, Philip Theodosopoulos, Edward Chang, Shawn Hervey-Jumper, Joanna J. Phillips, Melike Pekmezci, Andrew W. Bollen, Tarik Tihan, Susan Chang, Mitchel S. Berger, Arie Perry, David A. Solomon
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Acta Neuropathologica Communications
Subjects:
Rosette-forming glioneuronal tumor (RGNT)
Extraventricular neurocytoma (EVN)
Dysembryoplastic neuroepithelial tumor (DNT)
Pilocytic astrocytoma
FGFR1
PIK3CA
Online Access:http://link.springer.com/article/10.1186/s40478-020-01027-z

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http://link.springer.com/article/10.1186/s40478-020-01027-z

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