A Hypothesized Mechanism for Chronic Pancreatitis Caused by the N34S Mutation of Serine Protease Inhibitor Kazal-Type 1 Based on Conformational Studies

A Hypothesized Mechanism for Chronic Pancreatitis Caused by the N34S Mutation of Serine Protease Inhibitor Kazal-Type 1 Based on Conformational Studies

Martin Kulke,1 Felix Nagel,1 Lukas Schulig,2 Norman Geist,1 Marcel Gabor,1 Julia Mayerle,3 Markus M Lerch,4 Andreas Link,2 Mihaela Delcea1 1Institute of Biochemistry, University of Greifswald, Greifswald, Germany; 2Institute of Pharmacy, University of Greifswald, Greifswald, Germany; 3Department of...

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Bibliographic Details
Main Authors: Kulke M, Nagel F, Schulig L, Geist N, Gabor M, Mayerle J, Lerch MM, Link A, Delcea M
Format: Article
Language:English
Published: Dove Medical Press 2021-05-01
Series:Journal of Inflammation Research
Subjects:
trypsin
molecular dynamics simulations
replica exchange
transition path sampling
umbrella sampling
Online Access:https://www.dovepress.com/a-hypothesized-mechanism-for-chronic-pancreatitis-caused-by-the-n34s-m-peer-reviewed-fulltext-article-JIR

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https://www.dovepress.com/a-hypothesized-mechanism-for-chronic-pancreatitis-caused-by-the-n34s-m-peer-reviewed-fulltext-article-JIR

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