Long Read Single-Molecule Real-Time Sequencing Elucidates Transcriptome-Wide Heterogeneity and Complexity in Esophageal Squamous Cells

Long Read Single-Molecule Real-Time Sequencing Elucidates Transcriptome-Wide Heterogeneity and Complexity in Esophageal Squamous Cells

Esophageal squamous cell carcinoma is a leading cause of cancer death. Mapping the transcriptional landscapes such as isoforms, fusion transcripts, as well as long noncoding RNAs have played a central role to understand the regulating mechanism during malignant processes. However, canonical methods...

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Bibliographic Details
Main Authors: Yin-Wei Cheng, Yun-Mei Chen, Qian-Qian Zhao, Xing Zhao, Ya-Ru Wu, Dan-Ze Chen, Lian-Di Liao, Yang Chen, Qian Yang, Li-Yan Xu, En-Min Li, Jian-Zhen Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Genetics
Subjects:
heterogeneity
long reads sequencing
esophageal squamous cell carcinoma
transcriptome
alternative splicing
lincRNA
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00915/full

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https://www.frontiersin.org/article/10.3389/fgene.2019.00915/full

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