Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV

Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV

Abstract Congenital hypothyroidism (CH), a common neonatal endocrine disorder, can result in cognitive deficits if delay in diagnose and treatment. Dentate gyrus (DG) is the severely affected subregion of the hippocampus by the CH, where the dentate granule cells (DGCs) reside in. However, how CH im...

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Bibliographic Details
Main Authors: Qingying Tang, Shuxia Chen, Hui Wu, Honghua Song, Yongjun Wang, Jinlong Shi, Youjia Wu
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00530-z

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https://doi.org/10.1038/s41420-021-00530-z

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