Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class

Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class

Summary: Antibodies with heavy chains that derive from the VH1-2 gene constitute some of the most potent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing antibodies yet identified. To provide insight into whether these genetic similarities inform common modes of recognition,...

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Bibliographic Details
Main Authors: Micah Rapp, Yicheng Guo, Eswar R. Reddem, Jian Yu, Lihong Liu, Pengfei Wang, Gabriele Cerutti, Phinikoula Katsamba, Jude S. Bimela, Fabiana A. Bahna, Seetha M. Mannepalli, Baoshan Zhang, Peter D. Kwong, Yaoxing Huang, David D. Ho, Lawrence Shapiro, Zizhang Sheng
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
COVID-19
multi-donor antibody class
neutralizing antibody
quaternary recognition
RBD
SARS-CoV-2
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002643

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http://www.sciencedirect.com/science/article/pii/S2211124721002643

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