Construction and Functional Characterization of a Fully Human Anti-mesothelin Chimeric Antigen Receptor (CAR) Expressing T Cell

Construction and Functional Characterization of a Fully Human Anti-mesothelin Chimeric Antigen Receptor (CAR) Expressing T Cell

Chimeric antigen receptor (CAR) T cell therapy is considered as an encouraging approach for the treatment of hematological malignancies. However, its efficacy in solid tumors has not been satisfying, mainly in the immunosuppressive network of the tumor microenvironment and paucity of appropriate ta...

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Bibliographic Details
Main Authors: Leila Jafarzadeh, Elham Masoumi, Khadijeh Alishah, Hamid Reza Mirzaei, Arezoo Jamali, Keyvan Fallah-Mehrjardi, Hosein Rostamian, Mohammad Khakpoor-Koosheh, Reza Meshkani, Farshid Noorbakhsh, Jamshid Hadjati
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2020-06-01
Series:Iranian Journal of Allergy, Asthma and Immunology
Subjects:
Adoptive immunotherapy
Chimeric antigen receptor
Mesothelin
Online Access:https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2670

Internet

https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2670

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