Peripheral T cell receptor repertoire features predict durable responses to anti-PD-1 inhibitor monotherapy in advanced renal cell carcinoma

Peripheral T cell receptor repertoire features predict durable responses to anti-PD-1 inhibitor monotherapy in advanced renal cell carcinoma

Immune checkpoint inhibitors (ICIs) offer significant clinical benefits to a subset of cancer patients via the induction of a systemic T cell-mediated anti-cancer immune response. Thus, the dynamic characterization of T cell repertoires in the peripheral blood has the potential to demonstrate noninv...

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Bibliographic Details
Main Authors: Taigo Kato, Kazuma Kiyotani, Eisuke Tomiyama, Yoko Koh, Makoto Matsushita, Yujiro Hayashi, Kosuke Nakano, Yu Ishizuya, Cong Wang, Koji Hatano, Atsunari Kawashima, Takeshi Ujike, Kazutoshi Fujita, Norio Nonomura, Motohide Uemura
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
immune checkpoint inhibitors
predictive marker
t cell receptor
renal cell carcinoma
next-generation sequencing
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1862948

Internet

http://dx.doi.org/10.1080/2162402X.2020.1862948

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