The lncRNA NEAT1 promotes the epithelial-mesenchymal transition and metastasis of osteosarcoma cells by sponging miR-483 to upregulate STAT3 expression

The lncRNA NEAT1 promotes the epithelial-mesenchymal transition and metastasis of osteosarcoma cells by sponging miR-483 to upregulate STAT3 expression

Abstract Background Osteosarcoma is one of the most prevalent primary bone tumours in adolescents. Accumulating evidence shows that aberrant expression of the long non-coding RNA (lncRNA) NEAT1 and microRNA-483 (miR-483) contribute to the epithelial-mesenchymal transition (EMT), invasion and metasta...

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Bibliographic Details
Main Authors: Yan Chen, Jun Li, Jia-Kun Xiao, Lei Xiao, Bin-Wu Xu, Chen Li
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Cancer Cell International
Subjects:
Osteosarcoma
miR-483
NEAT1
STAT3
Epithelial-mesenchymal transition (EMT)
Metastasis
Online Access:https://doi.org/10.1186/s12935-021-01780-8

Internet

https://doi.org/10.1186/s12935-021-01780-8

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