Novel Types of Small RNA Exhibit Sequence- and Target-dependent Angiogenesis Suppression Without Activation of Toll-like Receptor 3 in an Age-related Macular Degeneration (AMD) Mouse Model

Novel Types of Small RNA Exhibit Sequence- and Target-dependent Angiogenesis Suppression Without Activation of Toll-like Receptor 3 in an Age-related Macular Degeneration (AMD) Mouse Model

RNA interference (RNAi) has become a powerful tool for suppressing gene expression in vitro and in vivo. A great deal of evidence has demonstrated the potential for the use of synthetic small interfering RNAs (siRNAs) as therapeutic agents. However, the application of siRNA to clinical medicine is s...

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Bibliographic Details
Main Authors: Masakatsu Takanashi, Katsuko Sudo, Shinobu Ueda, Shin-Ichiro Ohno, Yuko Yamada, Yasuhiro Osakabe, Hiroshi Goto, Yoshimichi Matsunaga, Akio Ishikawa, Yoshihiko Usui, Masahiko Kuroda
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
innate immune
molecular target therapy
RNAi
TLR
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116300439

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http://www.sciencedirect.com/science/article/pii/S2162253116300439

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