Continuous Cultivation as a Tool Toward the Rational Bioprocess Development With Pichia Pastoris Cell Factory

Continuous Cultivation as a Tool Toward the Rational Bioprocess Development With Pichia Pastoris Cell Factory

The methylotrophic yeast Pichia pastoris (Komagataella phaffii) is currently considered one of the most promising hosts for recombinant protein production (RPP) and metabolites due to the availability of several tools to efficiently regulate the recombinant expression, its ability to perform eukaryo...

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Bibliographic Details
Main Authors: Miguel Angel Nieto-Taype, Xavier Garcia-Ortega, Joan Albiol, José Luis Montesinos-Seguí, Francisco Valero
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Pichia pastoris
continuous cultivation
steady-state omics
physiological characterization
rational bioprocess development
bioreaction kinetics
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00632/full

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https://www.frontiersin.org/article/10.3389/fbioe.2020.00632/full

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