Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies.

Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies.

Human Cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant patients and in fetuses following congenital infection. The glycoprotein complexes gH/gL/gO and gH/gL/UL128/UL130/UL131A (Pentamer) are required for HCMV entry in fibroblasts and endothelial/epithelial cells, resp...

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Bibliographic Details
Main Authors: Claudio Ciferri, Sumana Chandramouli, Alexander Leitner, Danilo Donnarumma, Michael A Cianfrocco, Rachel Gerrein, Kristian Friedrich, Yukti Aggarwal, Giuseppe Palladino, Ruedi Aebersold, Nathalie Norais, Ethan C Settembre, Andrea Carfi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4617720?pdf=render

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http://europepmc.org/articles/PMC4617720?pdf=render

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