Mitophagy in Parkinson’s Disease: Pathogenic and Therapeutic Implications

Mitophagy in Parkinson’s Disease: Pathogenic and Therapeutic Implications

Neurons affected in Parkinson’s disease (PD) experience mitochondrial dysfunction and bioenergetic deficits that occur early and promote the disease-related α-synucleinopathy. Emerging findings suggest that the autophagy-lysosome pathway, which removes damaged mitochondria (mitophagy), is also compr...

Full description

Bibliographic Details
Main Authors: Fei Gao, Jia Yang, Dongdong Wang, Chao Li, Yi Fu, Huaishan Wang, Wei He, Jianmin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Neurology
Subjects:
mitophagy
Parkinson disease
mitochondria
synuclein
autophagosome
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2017.00527/full

Internet

http://journal.frontiersin.org/article/10.3389/fneur.2017.00527/full

Similar Items