Comparison of Toxicity and Toxicokinetics/Pharmacokinetics of an α1L-Adrenoceptor Agonist in Rats and Rhesus Monkeys
We have investigated the toxicity of an α1L-adrenoceptor agonist, ESR 1150 CL, and compared the toxicokinetics and pharmacokinetics in rats and monkeys. In rats, this compound induced death with remarkable sacculated aneurysms of the aorta in groups given more than 3mg/kg per day in a 4-week repeate...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2005-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319322789 |