Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein.
Intrinsic immunity relies on specific recognition of viral epitopes to mount a cell-autonomous defense against viral infections. Viral recognition determinants in intrinsic immunity genes are expected to evolve rapidly as host genes adapt to changing viruses, resulting in a signature of adaptive evo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-01-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2213710?pdf=render |