Tumor-Preferential Induction of Immune Responses and Epidermal Cell Death in Actinic Keratoses by Ingenol Mebutate.

UNLABELLED:The rapid and strong clinical efficacy of the first-in-class, ingenol mebutate, against actinic keratosis (AK) has resulted in its recent approval. We conducted the first comprehensive analysis of the cellular and molecular mode of action of topical ingenol mebutate 0.05% gel in both AK a...

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Bibliographic Details
Main Authors: Steffen Emmert, Holger A Haenssle, John R Zibert, Margarete Schön, Andreas Hald, Maria H Hansen, Thomas Litman, Michael P Schön
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5017628?pdf=render