Local IL-17 Production Exerts a Protective Role in Murine Experimental Glomerulonephritis.

IL-17 is a pro-inflammatory cytokine implicated in the pathogenesis of glomerulonephritis and IL-17 deficient mice are protected from nephrotoxic nephritis. However, a regulatory role for IL-17 has recently emerged. We describe a novel protective function for IL-17 in the kidney. Bone marrow chimera...

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Bibliographic Details
Main Authors: Sally Hamour, Poh-Yi Gan, Ruth Pepper, Fernanda Florez Barros, Hsu-Han Wang, Kim O'Sullivan, Yoichiro Iwakura, Terence Cook, Charles Pusey, Stephen Holdsworth, Alan Salama
Format: Article
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4552867?pdf=render