HIV-1 Uncoating and Nuclear Import Precede the Completion of Reverse Transcription in Cell Lines and in Primary Macrophages

HIV-1 Uncoating and Nuclear Import Precede the Completion of Reverse Transcription in Cell Lines and in Primary Macrophages

An assembly of capsid proteins (CA) form the mature viral core enclosing the HIV-1 ribonucleoprotein complex. Discrepant findings have been reported regarding the cellular sites and the extent of core disassembly (uncoating) in infected cells. Here, we combined single-virus imaging and time-of-drug-...

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Bibliographic Details
Main Authors: Ashwanth C. Francis, Mariana Marin, Mathew J. Prellberg, Kristina Palermino-Rowland, Gregory B. Melikyan
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Viruses
Subjects:
virus imaging
HIV-1 capsid
uncoating
reverse transcription
nuclear import
Online Access:https://www.mdpi.com/1999-4915/12/11/1234

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https://www.mdpi.com/1999-4915/12/11/1234

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