High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1

High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1

Fibroblast growth factor receptor 1 (FGFR1) is a plasma membrane protein that transmits signals from the extracellular environment, regulating cell homeostasis and function. Dysregulation of FGFR1 leads to the development of human cancers and noncancerous diseases. Numerous tumors overproduce FGFR1,...

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Bibliographic Details
Main Authors: Łukasz Opaliński, Jakub Szymczyk, Martyna Szczepara, Marika Kucińska, Daniel Krowarsch, Małgorzata Zakrzewska, Jacek Otlewski
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:International Journal of Molecular Sciences
Subjects:
affinity
cancer therapy
engineered antibodies
FGFR1
internalization
Online Access:http://www.mdpi.com/1422-0067/19/5/1435

Internet

http://www.mdpi.com/1422-0067/19/5/1435

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