Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4.

Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4.

Histone acetyltransferase 1 is an evolutionarily conserved type B histone acetyltransferase that is thought to be responsible for the diacetylation of newly synthesized histone H4 on lysines 5 and 12 during chromatin assembly. To understand the function of this enzyme in a complex organism, we have...

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Bibliographic Details
Main Authors: Prabakaran Nagarajan, Zhongqi Ge, Bianca Sirbu, Cheryl Doughty, Paula A Agudelo Garcia, Michaela Schlederer, Anthony T Annunziato, David Cortez, Lukas Kenner, Mark R Parthun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3675013?pdf=render

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http://europepmc.org/articles/PMC3675013?pdf=render

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