Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis.

Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis.

BACKGROUND:Norepinephrine (NE) modulates the responsiveness of macrophages to proinflammatory stimuli through the activation of adrenergic receptors (ARs). Being part of the stress response, early increases of NE in sepsis sustain adverse systemic inflammatory responses. The intestine is an importan...

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Bibliographic Details
Main Authors: Michael Miksa, Padmalaya Das, Mian Zhou, Rongqian Wu, Weifeng Dong, Youxin Ji, Sanna M Goyert, Thanjavur S Ravikumar, Ping Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2677660?pdf=render

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http://europepmc.org/articles/PMC2677660?pdf=render

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