The Role of Brain-Derived Neurotrophic Factor in Bone Marrow Stromal Cell-Mediated Spinal Cord Repair

The ability of intraspinal bone marrow stromal cell (BMSC) transplants to elicit repair is thought to result from paracrine effects by secreted trophic factors including brain-derived neurotrophic factor (BDNF). Here we used gene therapy to increase or silence BDNF production in BMSCs to investigate...

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Bibliographic Details
Main Authors: Gaby J. Ritfeld, Ajay Patel, Alexander Chou, Tabitha L. Novosat, Deborah G. Castillo, Raymund A. C. Roos, Martin Oudega Ph.D.
Format: Article
Language:English
Published: SAGE Publishing 2015-11-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368915X686201