Changes in gene expression in human skeletal stem cells transduced with constitutively active Gsα correlates with hallmark histopathological changes seen in fibrous dysplastic bone.

Changes in gene expression in human skeletal stem cells transduced with constitutively active Gsα correlates with hallmark histopathological changes seen in fibrous dysplastic bone.

Fibrous dysplasia (FD) of bone is a complex disease of the skeleton caused by dominant activating mutations of the GNAS locus encoding for the α subunit of the G protein-coupled receptor complex (Gsα). The mutation involves a substitution of arginine at position 201 by histidine or cysteine (GsαR201...

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Main Authors: Domenico Raimondo, Cristina Remoli, Letizia Astrologo, Romina Burla, Mattia La Torre, Fiammetta Vernì, Enrico Tagliafico, Alessandro Corsi, Simona Del Giudice, Agnese Persichetti, Giuseppe Giannicola, Pamela G Robey, Mara Riminucci, Isabella Saggio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0227279

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https://doi.org/10.1371/journal.pone.0227279

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