Convalescent Immunity to Guinea Pig Cytomegalovirus Induces Limited Cross Strain Protection against Re-Infection but High-Level Protection against Congenital Disease

Convalescent Immunity to Guinea Pig Cytomegalovirus Induces Limited Cross Strain Protection against Re-Infection but High-Level Protection against Congenital Disease

The guinea pig is the only small animal model for congenital cytomegalovirus (cCMV) but requires guinea pig cytomegalovirus (GPCMV). Current GPCMV research utilizes prototype strain 22122, which limits the translational impact of GPCMV as numerous human CMV strains exist and cCMV is possible in the...

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Bibliographic Details
Main Authors: K. Yeon Choi, Nadia S. El-Hamdi, Alistair McGregor
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
guinea pig
cytomegalovirus
vaccine
glycoproteins
neutralizing antibody
congenital CMV
Online Access:https://www.mdpi.com/1422-0067/21/17/5997

Internet

https://www.mdpi.com/1422-0067/21/17/5997

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