T cell receptor signaling defines the fate and pathway of ICOS internalization

The role of the inducible costimulatory of T cells (ICOS) has been shown to be important for many different T cell outcomes and is indispensable for follicular helper T cell (TFH) responses. Since its discovery, there have been several studies on the regulation of ICOS at a transcriptional level. Ho...

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Bibliographic Details
Main Authors: Joseph C. Lownik, Daniel H. Conrad, Rebecca K. Martin
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
TFH
CD3
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580820301138