Selective rab11 transport and the intrinsic regenerative ability of CNS axons

Selective rab11 transport and the intrinsic regenerative ability of CNS axons

Neurons lose intrinsic axon regenerative ability with maturation, but the mechanism remains unclear. Using an in-vitro laser axotomy model, we show a progressive decline in the ability of cut CNS axons to form a new growth cone and then elongate. Failure of regeneration was associated with increased...

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Bibliographic Details
Main Authors: Hiroaki Koseki, Matteo Donegá, Brian YH Lam, Veselina Petrova, Susan van Erp, Giles SH Yeo, Jessica CF Kwok, Charles ffrench-Constant, Richard Eva, James W Fawcett
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
axon regeneration
trafficking
axonal transport
endosomes
small GTPases
axotomy
Online Access:https://elifesciences.org/articles/26956

Internet

https://elifesciences.org/articles/26956

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