Digital-Droplet PCR for Quantification of CD19-Directed CAR T-Cells

Digital-Droplet PCR for Quantification of CD19-Directed CAR T-Cells

CD19-directed CAR-T-cells (CD19-CAR) have demonstrated remarkable clinical results in patients suffering from refractory or relapsed lymphoma and acute lymphoblastic leukemia. In order to further optimize follow-up, to explain treatment failure, and to control adverse events biomarkers for monitorin...

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Bibliographic Details
Main Authors: Thomas Mika, Abdelouahid Maghnouj, Susanne Klein-Scory, Swetlana Ladigan-Badura, Alexander Baraniskin, Julia Thomson, Justin Hasenkamp, Stephan A. Hahn, Gerald Wulf, Roland Schroers
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
CD19-directed chimeric antigen receptor (CAR) T-cells
axicabtagene ciloleucel
aggressive lymphoma
digital-droplet PCR (ddPCR)
flow cytometry (FCM)
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00084/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2020.00084/full

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