Optogenetic interrogation reveals separable G-protein-dependent and -independent signalling linking G-protein-coupled receptors to the circadian oscillator

Optogenetic interrogation reveals separable G-protein-dependent and -independent signalling linking G-protein-coupled receptors to the circadian oscillator

Abstract Background Endogenous circadian oscillators distributed across the mammalian body are synchronised among themselves and with external time via a variety of signalling molecules, some of which interact with G-protein-coupled receptors (GPCRs). GPCRs can regulate cell physiology via pathways...

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Bibliographic Details
Main Authors: Helena J. Bailes, Nina Milosavljevic, Ling-Yu Zhuang, Elliot J. Gerrard, Tomoki Nishiguchi, Takeaki Ozawa, Robert J. Lucas
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Biology
Subjects:
HEK293 Cell
Circadian Clock
Phase Response Curve
Proximity Ligation Assay
Rat1 Fibroblast
Online Access:http://link.springer.com/article/10.1186/s12915-017-0380-8

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http://link.springer.com/article/10.1186/s12915-017-0380-8

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