Association of FMO3 Variants and Trimethylamine N-Oxide Concentration, Disease Progression, and Mortality in CKD Patients.

Elevated levels of circulating pro-atherogenic uremic solutes, particularly trimethylamine N-oxide (TMAO), have been implicated in cardiovascular disease development in patients with chronic kidney disease (CKD). TMAO is generated from trimethylamine (TMA) via metabolism by hepatic flavin-containing...

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Bibliographic Details
Main Authors: Cassianne Robinson-Cohen, Richard Newitt, Danny D Shen, Allan E Rettie, Bryan R Kestenbaum, Jonathan Himmelfarb, Catherine K Yeung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4981377?pdf=render