5′-tiRNA-Cys-GCA regulates VSMC proliferation and phenotypic transition by targeting STAT4 in aortic dissection

5′-tiRNA-Cys-GCA regulates VSMC proliferation and phenotypic transition by targeting STAT4 in aortic dissection

Accumulating evidence shows that tRNA-derived fragments are a novel class of functional small non-coding RNA; however, their roles in aortic dissection (AD) are still unknown. In this study, we found that 5′-tiRNA-Cys-GCA was significantly downregulated in human and mouse models of aortic dissection...

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Bibliographic Details
Main Authors: Tingyu Zong, Yanyan Yang, Xiaotong Lin, Shaoyan Jiang, Hui Zhao, Meixin Liu, Yuanyuan Meng, Yong Li, Liang Zhao, Guozhang Tang, Kun Gong, Zhibin Wang, Tao Yu
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
5′-tiRNA
aortic dissection
cell proliferation
cell migration
phenotypic transition
STAT4
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121001815

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http://www.sciencedirect.com/science/article/pii/S2162253121001815

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