Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia

Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia

Background: Acute lymphoblastic leukaemia with mixed lineage leukaemia gene rearrangement (MLL-ALL) frequently affects infants and is associated with a poor prognosis. Primary refractory and relapsed disease due to resistance to glucocorticoids (GCs) remains a substantial hurdle to improving clinica...

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Bibliographic Details
Main Authors: Anne P. de Groot, Yoriko Saito, Eiryo Kawakami, Mari Hashimoto, Yuki Aoki, Rintaro Ono, Ikuko Ogahara, Saera Fujiki, Akiko Kaneko, Kaori Sato, Hiroshi Kajita, Takashi Watanabe, Masatoshi Takagi, Daisuke Tomizawa, Katsuyoshi Koh, Mariko Eguchi, Eiichi Ishii, Osamu Ohara, Leonard D. Shultz, Shuki Mizutani, Fumihiko Ishikawa
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:EBioMedicine
Subjects:
Humanized mouse
MLL
Leukaemia
Apoptosis
Xenograft
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421000281

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http://www.sciencedirect.com/science/article/pii/S2352396421000281

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