Mechanisms of cyclic nucleotide phosphodiesterases in modulating T cell responses in murine graft-versus-host disease.

Mechanisms of cyclic nucleotide phosphodiesterases in modulating T cell responses in murine graft-versus-host disease.

Graft-versus-host disease (GvHD) is a key contributor to the morbidity and mortality after allogeneic hematopoetic stem cell transplantation (HSCT). Regulatory Foxp3(+) CD4(+) T cells (Treg) suppress conventional T cell activation and can control GvHD. In our previous work, we demonstrate that a bas...

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Bibliographic Details
Main Authors: Michael Weber, Corinna Lupp, Pamela Stein, Andreas Kreft, Tobias Bopp, Thomas C Wehler, Edgar Schmitt, Hansjörg Schild, Markus P Radsak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3590136?pdf=render

Internet

http://europepmc.org/articles/PMC3590136?pdf=render

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