Piperine Inhibits TGF-β Signaling Pathways and Disrupts EMT-Related Events in Human Lung Adenocarcinoma Cells

Piperine Inhibits TGF-β Signaling Pathways and Disrupts EMT-Related Events in Human Lung Adenocarcinoma Cells

<b>Background:</b> Piperine, an amide extracted from the Piper spices, exhibits strong anti-tumor properties. However, its effect on the epithelial–mesenchymal transition (EMT) process has never been investigated. Herein, we evaluate the toxic effect of piperine on lung adenocarcinoma (A...

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Bibliographic Details
Main Authors: Leonardo Marques da Fonseca, Lucas Rodrigues Jacques da Silva, Jhenifer Santos dos Reis, Marcos André Rodrigues da Costa Santos, Victoria de Sousa Chaves, Kelli Monteiro da Costa, Julliana de Nazareth Sa-Diniz, Celio Geraldo Freire de Lima, Alexandre Morrot, Tatiany Nunes Franklim, Douglas Chaves de Alcântara-Pinto, Marco Edilson Freire de Lima, Jose Osvaldo Previato, Lucia Mendonça-Previato, Leonardo Freire-de-Lima
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Medicines
Subjects:
piperine
cancer
piperidinyl amide
epithelial–mesenchymal transition
ERK1/2
SMAD
Online Access:https://www.mdpi.com/2305-6320/7/4/19

Internet

https://www.mdpi.com/2305-6320/7/4/19

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