Allopregnanolone mediates the exacerbation of Tourette-like responses by acute stress in mouse models

Abstract Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple tics and sensorimotor abnormalities, the severity of which is typically increased by stress. The neurobiological underpinnings of this exacerbation, however, remain elusive. We recently reported that spatial con...

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Bibliographic Details
Main Authors: Laura J. Mosher, Sean C. Godar, Marianela Nelson, Stephen C. Fowler, Graziano Pinna, Marco Bortolato
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-03649-1