Loss of 5-Hydroxymethylcytosine as an Epigenetic Signature That Correlates With Poor Outcomes in Patients With Medulloblastoma

Loss of 5-Hydroxymethylcytosine as an Epigenetic Signature That Correlates With Poor Outcomes in Patients With Medulloblastoma

Medulloblastoma, as the most common malignant brain tumor in children, exhibits highly dysregulated DNA methylation. The novel epigenetic marker—5-hydroxymethylcytosine (5hmC) plays essential role in gene regulation during brain development and in brain tumors. However, the biological and clinical i...

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Bibliographic Details
Main Authors: Fu Zhao, Zhi-Wei Zhang, Jing Zhang, Shun Zhang, Heng Zhang, Chi Zhao, Yang Chen, Lin Luo, Wei-Min Tong, Chunde Li, Yamei Niu, Pinan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
medulloblastoma
5-hydroxymethylcytosine
prognosis
Ki-67
epigenetics
immunohistochemistry
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.603686/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.603686/full

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