The potassium channel KCa3.1 represents a valid pharmacological target for microgliosis-induced neuronal impairment in a mouse model of Parkinson’s disease

The potassium channel KCa3.1 represents a valid pharmacological target for microgliosis-induced neuronal impairment in a mouse model of Parkinson’s disease

Abstract Background Recent studies described a critical role for microglia in Parkinson’s disease (PD), where these central nerve system resident immune cells participate in the neuroinflammatory microenvironment that contributes to dopaminergic neurons loss in the substantia nigra. Understanding th...

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Bibliographic Details
Main Authors: Jia Lu, Fangfang Dou, Zhihua Yu
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Neuroinflammation
Subjects:
KCa3.1
Orai1
Microglia
Neuroinflammatory
Senicapoc
Online Access:https://doi.org/10.1186/s12974-019-1682-2

Internet

https://doi.org/10.1186/s12974-019-1682-2

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