Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases

Neurons affected in a wide variety of unrelated adult-onset neurodegenerative diseases (AONDs) typically exhibit a “dying back” pattern of degeneration, which is characterized by early deficits in synaptic function and neuritic pathology long before neuronal cell death. Consistent with this observat...

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Bibliographic Details
Main Authors: Scott T. Brady, Gerardo A. Morfini
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117300840