Synthesis of Hydrophobic Propionyl Neohesperidin Ester Using an Immobilied Enzyme and Description of Its Anti-proliferative and Pro-apoptotic Effects on MCF-7 Human Breast Cancer Cells

Synthesis of Hydrophobic Propionyl Neohesperidin Ester Using an Immobilied Enzyme and Description of Its Anti-proliferative and Pro-apoptotic Effects on MCF-7 Human Breast Cancer Cells

Neohesperidin (NH) is a natural flavonoid glycoside compound with considerable physiological and pharmacological activities. However, its bioavailability is limited due to poor solubility, and few studies have so far attempted improve the solubility and bioavailability of NH. In this study, we struc...

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Bibliographic Details
Main Authors: Na Xia, Wenjing Wan, Siming Zhu, Qiang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
esterification modification using immobilized enzyme
propionyl neohesperidin ester
lipophilicity of neohesperidin
apoptosis of breast cancer cells
MCF-7
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.01025/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.01025/full

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