PMMA-Based Continuous Hemofiltration Modulated Complement Activation and Renal Dysfunction in LPS-Induced Acute Kidney Injury

PMMA-Based Continuous Hemofiltration Modulated Complement Activation and Renal Dysfunction in LPS-Induced Acute Kidney Injury

Sepsis-induced acute kidney injury (AKI) is a frequent complication in critically ill patients, refractory to conventional treatments. Aberrant activation of innate immune system may affect organ damage with poor prognosis for septic patients. Here, we investigated the efficacy of polymethyl methacr...

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Bibliographic Details
Main Authors: Alessandra Stasi, Rossana Franzin, Chiara Divella, Fabio Sallustio, Claudia Curci, Angela Picerno, Paola Pontrelli, Francesco Staffieri, Luca Lacitignola, Antonio Crovace, Vincenzo Cantaluppi, Davide Medica, Claudio Ronco, Massimo de Cal, Anna Lorenzin, Monica Zanella, Giovanni B. Pertosa, Giovanni Stallone, Loreto Gesualdo, Giuseppe Castellano
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
LPS-induced AKI
PMMA-CVVH treatment
immunological dysfunction
complement modulation
gene expression profile
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.605212/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.605212/full

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