Enhanced Control of Oncolytic Measles Virus Using MicroRNA Target Sites

Enhanced Control of Oncolytic Measles Virus Using MicroRNA Target Sites

Measles viruses derived from the live-attenuated Edmonton-B vaccine lineage are currently investigated as novel anti-cancer therapeutics. In this context, tumor specificity and oncolytic potency are key determinants of the therapeutic index. Here, we describe a systematic and comprehensive analysis...

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Main Authors: Mathias Felix Leber, Marc-Andrea Baertsch, Sophie Caroline Anker, Luisa Henkel, Hans Martin Singh, Sascha Bossow, Christine E. Engeland, Russell Barkley, Birgit Hoyler, Jessica Albert, Christoph Springfeld, Dirk Jäger, Christof von Kalle, Guy Ungerechts
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Molecular Therapy: Oncolytics
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770518300093

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http://www.sciencedirect.com/science/article/pii/S2372770518300093

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