Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus.

Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus.

The fast evolving human KIR gene family encodes variable lymphocyte receptors specific for polymorphic HLA class I determinants. Nucleotide sequences for 24 representative human KIR haplotypes were determined. With three previously defined haplotypes, this gave a set of 12 group A and 15 group B hap...

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Bibliographic Details
Main Authors: Chul-Woo Pyo, Lisbeth A Guethlein, Quyen Vu, Ruihan Wang, Laurent Abi-Rached, Paul J Norman, Steven G E Marsh, Jeffrey S Miller, Peter Parham, Daniel E Geraghty
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3012066?pdf=render

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http://europepmc.org/articles/PMC3012066?pdf=render

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